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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">GLUT-3</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_2.A.1.1.12" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">GLUT-3
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">496 Aminosäuren
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<td><a href="Sekund%C3%A4rstruktur" title="Sekundärstruktur">Sekundär-</a> bis <a href="Quart%C3%A4rstruktur" title="Quartärstruktur">Quartärstruktur</a>
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<td colspan="2" style="text-align:center;">multipass (12 TMS) Membranprotein
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Name</a>
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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=11107">SLC2A3</a></i>
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<td>Externe IDs
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<td colspan="2" class="">
<ul><li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/138170">138170</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P11169">P11169</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Transporter-Klassifikation
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<td><a href="Transporter_Classification_Database" title="Transporter Classification Database">TCDB</a>
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<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://tcdb.org/search/result.php?tc=2.A.1.1.12">2.A.1.1.12</a>
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<td><a href="Membrantransport" title="Membrantransport">Bezeichnung</a>
</td>
<td colspan="2" style="text-align:center;"><a href="Major-Facilitator-Superfamilie" title="Major-Facilitator-Superfamilie">Major-Facilitator-Superfamilie</a> / <a href="Glucosetransporter" title="Glucosetransporter">Glucosetransporter</a>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P11169">Hovergen</a>
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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>
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<td colspan="2" style="text-align:center;"><a href="Mehrzellige_Tiere" class="mw-redirect" title="Mehrzellige Tiere">mehrzellige Tiere</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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</tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>GLUT-3 (Glucosetransporter Typ 3)</b> (<a href="Gen" title="Gen">Gen</a>: <i>SLC2A3</i>) heißt das <a href="Protein" title="Protein">Protein</a>, das besonders in der <a href="Zellmembran" title="Zellmembran">Zellmembran</a> der <a href="Neuron" class="mw-redirect" title="Neuron">Neuronen</a> von <a href="Tiere" class="mw-redirect" title="Tiere">Tieren</a> lokalisiert ist und die Ein- bzw. Ausschleusung von <a href="Glucose" title="Glucose">Glucose</a> sowie von <a href="Dehydroascorbat" class="mw-redirect" title="Dehydroascorbat">Dehydroascorbat</a> erleichtert. Es handelt sich um ein Membran-<a href="Transportprotein" title="Transportprotein">Transportprotein</a>. Beim Menschen ist GLUT-3 in geringem Maß auch in vielen anderen Gewebetypen vorhanden. Bei der <a href="Hausmaus" title="Hausmaus">Hausmaus</a> (<i>Mus musculus</i>) ist es eines der häufigsten Proteine in den <a href="Spermien" class="mw-redirect" title="Spermien">Spermien</a>.<sup id="cite_ref-u_2-0" class="reference"><a href="#cite_note-u-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p><p>Das entwicklungsgeschichtlich älteste Exemplar wurde in <i><a href="Nematostella_vectensis" title="Nematostella vectensis">Nematostella vectensis</a></i>, einer <a href="Seeanemone" class="mw-redirect" title="Seeanemone">Seeanemone</a> gefunden.
</p>
<div class="mw-heading mw-heading2"><h2 id="Funktion">Funktion</h2></div>
<p>In Neuronen wird die Expression von GLUT-3 durch Aktivität der AMP-Kinase reguliert. Dieser Prozess ist ein wichtiger Teil der Unempfindlichkeit von Neuronen gegenüber <a href="Excitotoxizit%C3%A4t" title="Excitotoxizität">Excitotoxizität</a> (Überaktivierung von <a href="Glutamatrezeptor" title="Glutamatrezeptor">Glutamatrezeptoren</a>). Auch in der frühen Entwicklungsphase des Embryos ist GLUT-3 unentbehrlich.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Weiterführende_Literatur"><span id="Weiterf.C3.BChrende_Literatur"></span>Weiterführende Literatur</h2></div>
<ul><li>Maulén NP, Henríquez EA, Kempe S, <i>et al.</i>: <cite style="font-style:italic">Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells</cite>. In: <cite style="font-style:italic">J. Biol. Chem.</cite> 278. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>11</span>, März 2003, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>9035–41</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1074/jbc.M205119200">10.1074/jbc.M205119200</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12381735?dopt=Abstract">PMID 12381735</a> (<a rel="nofollow" class="external text" href="http://www.jbc.org/content/278/11/9035.long">jbc.org</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=Up-regulation+and+polarized+expression+of+the+sodium-ascorbic+acid+transporter+SVCT1+in+post-confluent+differentiated+CaCo-2+cells&rft.au=Maul%C3%A9n+NP%2C+Henr%C3%ADquez+EA%2C+Kempe+S%2C+...&rft.date=2003-03&rft.doi=10.1074%2Fjbc.M205119200&rft.genre=journal&rft.issue=11&rft.jtitle=J.+Biol.+Chem.&rft.pages=9035-41&rft.pmid=12381735&rft.volume=278.+Jahrgang" style="display:none"> </span></li>
<li>Rumsey SC, Kwon O, Xu GW, Burant CF, Simpson I, Levine M: <cite style="font-style:italic">Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid</cite>. In: <cite style="font-style:italic">J. Biol. Chem.</cite> 272. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>30</span>, Juli 1997, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>18982–9</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/9228080?dopt=Abstract">PMID 9228080</a> (<a rel="nofollow" class="external text" href="http://www.jbc.org/content/272/30/18982.long">jbc.org</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=Glucose+transporter+isoforms+GLUT1+and+GLUT3+transport+dehydroascorbic+acid&rft.au=Rumsey+SC%2C+Kwon+O%2C+Xu+GW%2C+...&rft.date=1997-07&rft.genre=journal&rft.issue=30&rft.jtitle=J.+Biol.+Chem.&rft.pages=18982-9&rft.pmid=9228080&rft.volume=272.+Jahrgang" style="display:none"> </span></li>
<li>Liang WJ, Johnson D, Jarvis SM: <cite style="font-style:italic">Vitamin C transport systems of mammalian cells</cite>. In: <cite style="font-style:italic">Mol. Membr. Biol.</cite> 18. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 2001, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>87–95</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11396616?dopt=Abstract">PMID 11396616</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=Vitamin+C+transport+systems+of+mammalian+cells&rft.au=Liang+WJ%2C+Johnson+D%2C+Jarvis+SM&rft.date=2001&rft.genre=journal&rft.issue=1&rft.jtitle=Mol.+Membr.+Biol.&rft.pages=87-95&rft.pmid=11396616&rft.volume=18.+Jahrgang" style="display:none"> </span></li>
<li>Rivas CI, Zúñiga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC: <cite style="font-style:italic">Vitamin C transporters</cite>. In: <cite style="font-style:italic">J. Physiol. Biochem.</cite> 64. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, Dezember 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>357–75</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19391462?dopt=Abstract">PMID 19391462</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=Vitamin+C+transporters&rft.au=Rivas+CI%2C+Z%C3%BA%C3%B1iga+FA%2C+Salas-Burgos+A%2C+...&rft.date=2008-12&rft.genre=journal&rft.issue=4&rft.jtitle=J.+Physiol.+Biochem.&rft.pages=357-75&rft.pmid=19391462&rft.volume=64.+Jahrgang" style="display:none"> </span></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>
<ul><li>D’Eustachio / reactome: <i><a rel="nofollow" class="external text" href="https://reactome.org/content/detail/R-HSA-198818">Dehydroascorbate transport across the plasma membrane</a></i></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002945">InterPro: Glucose transporter, type 3 (GLUT3)</a></span>
</li>
<li id="cite_note-u-2"><span class="mw-cite-backlink"><a href="#cite_ref-u_2-0">↑</a></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P11168">P11168</a></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002945">InterPro: <i>IPR002945 Glucose transporter, type 3 (GLUT3)</i></a></span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ: <cite style="font-style:italic">The facilitative glucose transporter GLUT3: 20 years of distinction</cite>. In: <cite style="font-style:italic">Am. J. Physiol. Endocrinol. Metab.</cite> 295. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, August 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>E242–53</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1152/ajpendo.90388.2008">10.1152/ajpendo.90388.2008</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18577699?dopt=Abstract">PMID 18577699</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519757/">PMC 2519757</a> (freier Volltext) – (<a rel="nofollow" class="external text" href="http://ajpendo.physiology.org/cgi/content/full/295/2/E242">physiology.org</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=The+facilitative+glucose+transporter+GLUT3%3A+20+years+of+distinction&rft.au=Simpson+IA%2C+Dwyer+D%2C+Malide+D%2C+...&rft.date=2008-08&rft.doi=10.1152%2Fajpendo.90388.2008&rft.genre=journal&rft.issue=2&rft.jtitle=Am.+J.+Physiol.+Endocrinol.+Metab.&rft.pages=E242-53&rft.pmc=2519757&rft.pmid=18577699&rft.volume=295.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Weisová P, Concannon CG, Devocelle M, Prehn JH, Ward MW: <cite style="font-style:italic">Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons</cite>. In: <cite style="font-style:italic">J. Neurosci.</cite> 29. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>9</span>, März 2009, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2997–3008</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1523/JNEUROSCI.0354-09.2009">10.1523/JNEUROSCI.0354-09.2009</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19261894?dopt=Abstract">PMID 19261894</a> (<a rel="nofollow" class="external text" href="http://www.jneurosci.org/cgi/content/full/29/9/2997">jneurosci.org</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=Regulation+of+glucose+transporter+3+surface+expression+by+the+AMP-activated+protein+kinase+mediates+tolerance+to+glutamate+excitation+in+neurons&rft.au=Weisov%C3%A1+P%2C+Concannon+CG%2C+Devocelle+M%2C+...&rft.date=2009-03&rft.doi=10.1523%2FJNEUROSCI.0354-09.2009&rft.genre=journal&rft.issue=9&rft.jtitle=J.+Neurosci.&rft.pages=2997-3008&rft.pmid=19261894&rft.volume=29.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">Schmidt S, Hommel A, Gawlik V, <i>et al.</i>: <cite style="font-style:italic">Essential role of glucose transporter GLUT3 for post-implantation embryonic development</cite>. In: <cite style="font-style:italic">J. Endocrinol.</cite> 200. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, Januar 2009, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>23–33</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1677/JOE-08-0262">10.1677/JOE-08-0262</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18948350?dopt=Abstract">PMID 18948350</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632781/">PMC 2632781</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:GLUT-3&rft.atitle=Essential+role+of+glucose+transporter+GLUT3+for+post-implantation+embryonic+development&rft.au=Schmidt+S%2C+Hommel+A%2C+Gawlik+V%2C+...&rft.date=2009-01&rft.doi=10.1677%2FJOE-08-0262&rft.genre=journal&rft.issue=1&rft.jtitle=J.+Endocrinol.&rft.pages=23-33&rft.pmc=2632781&rft.pmid=18948350&rft.volume=200.+Jahrgang" style="display:none"> </span></span>
</li>
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